The broad clinical development programme of NGR-hTNF includes Phase II trials in seven different types of solid tumours, as monotherapy in colorectal cancer, hepatocellular carcinoma and mesothelioma, or in combination with standard chemotherapeutic agents in small-cell lung cancer, non-small cell lung cancer, ovarian cancer and soft-tissue sarcoma.
Furthermore, NGR-hTNF was investigated in a Phase III trial in mesothelioma patients.

Currently, the randomised Phase II trial in mesothelioma as first-line maintenance therapy is ongoing.

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